History of Vaccines 

• Vaccines was first mentioned in the 1700’s in Chinese writing as a preventative measure against smallpox virus.  
• The first vaccine was actually developed by Edward Jenner in 1796 who found the cure for small box by injecting cow pox into a small boy who became immune to any forms of the orthodox virus.  
• The first live-attenuated or weakened virus vaccine was developed by Louis Pasteur in 1885 that eradicated the Rabies disease.  
• By the burst of the 20th century, Pasteur ideas for vaccine development resulted in the increase production of vaccines for various diseases including Killed or inactivated vaccines for cholera and typhoid.  

• By the 1940’s, there was introduction to in cell vitro cell culture which means vaccines were being developed without the use of host organisms this led to development of various vaccine for the Polio virus.  There was also the introduction of combination vaccines that resulted in the production of various being added together for example Diphtheria, tetanus, pertussis vaccines. 
•  In the 1970’s polysaccharide vaccines ( inactivated subunit vaccine composed of long chains of sugar molecules that make up the surface capsule of certain bacteria) were introduced which led to control of both invasive infections and spread of the organisms in the body. These vaccines help to alleviate illness that are cause from meningitis and pneumonia infections. 
•  As the 21st century emerged more innovated approach to vaccine development including Protein synthesis or Recombinant antigen vaccine brought forth the HBV vaccine All these vaccine developments have come to our aid in helping the world develop a vaccine more quickly and efficiently to eradicate the Covid-19 virus.                                                                                                 Image source: